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NSC 185058
CAS No. 39122-38-8
NSC 185058( NSC185058 | NSC-185058 | 2-Pyridinecarbothioamide )
Catalog No. M14346 CAS No. 39122-38-8
NSC 185058 (NSC185058, NSC-185058, 2-Pyridinecarbothioamide) is a novel ATG4B antagonist that inhibits autophagy with IC50 of 50 uM, with no effect on mTOR and PI3K activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 170 | In Stock |
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| 10MG | 267 | In Stock |
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| 25MG | 464 | In Stock |
|
| 50MG | 662 | In Stock |
|
| 100MG | 888 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNSC 185058
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NoteResearch use only, not for human use.
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Brief DescriptionNSC 185058 (NSC185058, NSC-185058, 2-Pyridinecarbothioamide) is a novel ATG4B antagonist that inhibits autophagy with IC50 of 50 uM, with no effect on mTOR and PI3K activities.
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DescriptionNSC 185058 (NSC185058, NSC-185058, 2-Pyridinecarbothioamide) is a novel ATG4B antagonist that inhibits autophagy with IC50 of 50 uM, with no effect on mTOR and PI3K activities; directly inhibits cellular ATG4B activity induced by starvation or rapamycin and suppresses the lipidation of LC3B and autophagosome formation in response to starvation, suppresses Saos-2 osteosarcoma growth in vivo; markedly slows tumor growth and provides a significant survival benefit in GBM xenografts combined with radiotherapy.
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In Vitro——
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In Vivo——
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SynonymsNSC185058 | NSC-185058 | 2-Pyridinecarbothioamide
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PathwayAutophagy
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TargetAtg
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RecptorATG4B|Autophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number39122-38-8
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Formula Weight215.274
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Molecular FormulaC11H9N3S
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Purity>98% (HPLC)
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SolubilityDMSO: 30 mg/mL, 139.36 mME; thanol: 2.5 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESS=C(C1=NC=CC=C1)NC2=NC=CC=C2
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Chemical NameN-pyridin-2-ylpyridine-2-carbothioamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Akin D, et al. Autophagy. 2014;10(11):2021-35.
2. Huang T, et al. Cancer Cell. 2017 Dec 11;32(6):840-855.e8.
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